Document Details
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Document Type |
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Article In Journal |
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Document Title |
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An update on the pathophysiology of osteoarthritis An update on the pathophysiology of osteoarthritis |
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Document Language |
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English |
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Abstract |
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Introduction: Osteoarthritis (OA) is one of the most common forms of arthritis. There is accumulating
evidence to suggest that OA is an inflammatory disease of the entire synovial joint and has multiple
phenotypes. This presents the OA research community with new challenges and opportunities. The main
challenge is to understand the root cause of the disease and identify differences and similarities between
OA phenotypes. The key opportunity is the possibility of developing personalized and individualized
prevention and treatment strategies for OA patients with different phenotypes of the disease. Indeed, it
has been suggested that this is the era of ‘personalized prevention’ for OA. The aim of this mini-review
paper is to focus on the pathophysiological aspects of OA development and progression, review the
current concepts and discuss the future of personalized medicine for OA.
Method: The PubMed/MEDLINE bibliographic database was searched using the keywords ‘pathophysi-
ology’ and ‘osteoarthritis’.
Results: The PubMed/MEDLINE search yielded more than 12,000 relevant papers. A selection of these
papers is reviewed here.
Conclusion: There has been slow but steady progress in our understanding of the pathophysiology of OA
over the last two decades. However, large gaps remain in our knowledge of OA pathogenesis and this
impacts negatively on patients and drug development pipeline. In the absence of new pharmaceutical
agents and disease modifying osteoarthritis drugs (DMOADs) it is clear that lifestyle modification and
physical activity are important and may delay the need for surgical intervention. |
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ISSN |
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1877-0657 |
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Journal Name |
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Annals of physical and rehabilitation medicine |
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Volume |
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59 |
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Issue Number |
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5 |
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Publishing Year |
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1437 AH
2016 AD |
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Article Type |
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Article |
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Added Date |
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Wednesday, July 12, 2017 |
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Researchers
| Mark Batt | Batt, Mark | Researcher | Doctorate | |
| Ali Mobasheri | Mobasheri, Ali | Researcher | | |
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